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Genisphere Awarded Patent for Whole Transcriptome Next Generation Sequencing

HATFIELD, Pa -
February 10, 2014 -

Genisphere LLC reported today it has been granted a US patent for a novel strand-specific library preparation method for next generation sequencing based on its proven RNA amplification technology. The new patented process enables amplification and library preparation from clinically relevant RNA samples, adapts easily to a variety of sequencing instruments and systems, and reduces the time required for sample preparation by eliminating labor intensive steps.

Genisphere’s RNA amplification technology employs a robust whole transcriptome amplification process that has been successfully integrated into several assay systems. In 2008, Genisphere’s amplification technology was incorporated into the Pathwork Diagnostics Tissue of Origin Test (now offered by Response Genetics), which was cleared by the FDA in 2010. In 2011, the latest version of the company’s amplification technology, trademarked Sensation®, was licensed to Affymetrix for microarray applications.

"Genisphere's technology for whole transcriptome amplification is a dynamic commonality among our diverse corporate initiatives, which include targeted therapeutics, clinical diagnostics, and life science", said Bob Getts, Genisphere’s Chief Science Officer. "We are pleased to offer these methods to our collaborators and partners who are interested in broadening their translational research initiatives in the areas of new drug discovery, diagnostic assay development, and moving next generation sequencing from the research lab to the clinic. We also see this as an excellent tool to complement our 3DNA nanoparticle technology used for targeted drug delivery since it will help to uncover those molecules that will be ideal targets for companion diagnostics based on next generation sequencing."

About Genisphere

Genisphere LLC is the provider of the 3DNA® platform for targeted drug delivery. 3DNA® is a nanoscale, multivalent scaffold made from proprietary, synthetic DNA formed in a flexible, branched structure. 3DNA® nanocarriers are engineered and cross-linked to form a stable architecture while maintaining the biocompatibility of the nucleic-acid building blocks, and demonstrate efficacy and safety with a variety of drug cargos across multiple indications. Genisphere's technology is IP-protected and fully customizable to deliver small molecules, biologics, and nucleic acids with precise specificity enabled by multivalent targeting via antibodies, peptides and other molecular entities. Genisphere leverages a collaborative model to advance its 3DNA® drug delivery platform, and seeks additional partnerships with biotechnology and pharmaceutical companies to improve efficacy and reduce toxicity. Genisphere is also advancing its own lead compounds based on 3DNA® nanotechnology. For more information, please visit http://genisphere.com.

For more information contact:

Bob Getts
CSO, Genisphere