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Publications & Patents

Drug Delivery

Antibody Conjugated, DNA-Based Nanocarriers Intercalated with Doxorubicin Eliminate Myofibroblasts in Explants of Human Lens Tissue
The Journal of Pharmacology and Experimental Therapeutics 2017;jpet.116.239079
doi: 10.1124/jpet.116.239079

The 3DNA Platform for Targeted Drug Delivery
Drug Development & Delivery November/December 2016

Local Reagent Makes Good
BioCentury Innovations June 2, 2016

Delivery of Therapeutics Targeting the mRNA-Binding Protein HuR Using 3DNA Nanocarriers Suppresses Ovarian Tumor Growth
Cancer Research 2016;76(6);1-11
doi: 10.1158/0008-5472.CAN-15-2073

DNA-Based Drug Carriers: The Paradox of a Classical “Cargo” Material Becoming a Versatile “Carrier” to Overcome Barriers in Drug Delivery
Current Pharmaceutical Design 2016;22(9);1245-1258
doi: 10.2174/1381612822666151216151614

On the Road Toward Solving the PCO Challenge
Ophthalmology Times 2015;40(12)

A DNA Device that Mediates Selective Endosomal Escape and Intracellular Delivery of Drugs and Biologicals
Advanced Functional Materials 2014;24:2899–2906
doi:10.1002/adfm.201303188

Functional Delivery of miR-218 Precursor in Primary Bronchial Epithelial Cells using 3DNA Nanotechnology
Genisphere White Paper October 14, 2013

Legacy 3DNA Products

Improving the Limit of Detection of Lateral Flow assays using 3DNA Technology
Genisphere White Paper July 16, 2014

Epitope Mapping of Atlantic Salmon Major Allergen by Peptide Microarray Immunoassay
International Archives of Allergy and Immunology 2012;157:31-40
doi: 10.1159/000324677

Bio/abiotic interface constructed from nanoscale DNA dendrimer and conducting polymer for ultrasensitive biomolecular diagnosis.
Small 2009;5(15);1784-1790
doi: 10.1002/smll.200900369

Protein detection enhanced by 3DNA dendrimer signal amplification
BioTechniques 2008;44:815-818
doi: 10.2144/000112733

Suspension Microarray with Dendrimer Signal Amplification Allows Direct and High-Throughput Subtyping of Listeria monocytogenes from Genomic DNA
Journal of Clinical Microbiology 2005;43(7);3255-3259
doi: 10.1128/​JCM.43.7.3255-3259.2005

Patents

Granted US Patents

Patent Number Title
5,175,270 Reagents for detecting and assaying nucleic acid sequences
5,484,904 Nucleic Acid Matrices
5,487,973 Methods for Detecting and Assaying Nucleic Acid Sequences
6,046,038 Optimally Labeled Oligonucleotides
6,072,043 Optimally Labeled Oligonucleotides
6,110,687 Detection of Antigens Via Oligonucleotide Antibody Conjugates
6,117,631 Detection of Antigens Via Oligonucleotide Antibody Conjugates
6,274,723 Dendritic Nucleic Acids Exhibiting Maximal Self-Assembly
6,762,292 Optimally Labeled Oligonucleotides
7,494,789 Methods for amplification of nucleic acid sequences using staggered ligation
7,550,264 Methods and kits for sense RNA synthesis
7,888,018 Methods and kits for nucleic acid amplification
8,097,418 Methods and kits for sense RNA synthesis
8,343,721 Methods and kits for nucleic acid amplification
8,617,817 Whole Transcriptome Sequencing
8,653,251 Methods and kits for nucleic acid amplification
8,685,899 Methods, reagents and kits for detection of nucleic acid molecules
8,802,867 Method for producing a sense RNA molecule

Granted International Patents

Patent Number Country Title
2610929 Canada Methods and Kits for Sense RNA Synthesis
187866 Israel Methods and Kits for Sense RNA Synthesis
1893626 Germany Methods and Kits for Sense RNA Synthesis
1893626 France Methods and Kits for Sense RNA Synthesis
1893626 United Kingdom Methods and Kits for Sense RNA Synthesis
5118025 Japan Methods and Kits for Sense RNA Synthesis
602005018530.5 Germany Methods for detection of micro RNA molecules
1812600 European Patent Office Methods for detection of micro RNA molecules
1812600 France Methods for detection of micro RNA molecules
1812600 United Kingdom Methods for detection of micro RNA molecules
1438435 Germany Methods for Blocking Nonspecific Hybridisations of Nucleic Acid Sequences
1438435 European Patent Office Methods for Blocking Nonspecific Hybridisations of Nucleic Acid Sequences
1438435 France Methods for Blocking Nonspecific Hybridisations of Nucleic Acid Sequences
1438435 United Kingdom Methods for Blocking Nonspecific Hybridisations of Nucleic Acid Sequences
60133111.7 Germany Methods For Detecting And Assaying Nucleic Acid Sequences
1319179 European Patent Office Methods For Detecting And Assaying Nucleic Acid Sequences
1319179 France Methods For Detecting And Assaying Nucleic Acid Sequences
1319179 United Kingdom Methods For Detecting And Assaying Nucleic Acid Sequences
60120118.3 Germany Methods for Assay and Detection on a Microarray
1261617 European Patent Office Methods for Assay and Detection on a Microarray
1261617 France Methods for Assay and Detection on a Microarray
1261617 United Kingdom Methods for Assay and Detection on a Microarray
ZL200580014395.X China Methods For Amplification of Nucleic Acid Sequences Using Promoter Templates
602005017252.1 Germany Methods For Amplification of Nucleic Acid Sequences Using Promoter Templates
1730314 European Patent Office Methods For Amplification of Nucleic Acid Sequences Using Promoter Templates
1730314 France Methods For Amplification of Nucleic Acid Sequences Using Promoter Templates
1730314 United Kingdom Methods For Amplification of Nucleic Acid Sequences Using Promoter Templates
4629095 Japan Methods For Amplification Of Nucleic Acid Sequences Using Promoter Templates
1730314 Netherlands Methods For Amplification of Nucleic Acid Sequences Using Promoter Templates
69735532.2 Germany Detection Of Antigens Via Oligonucleotide Antibody Conjugates
951297 European Patent Office Detection Of Antigens Via Oligonucleotide Antibody Conjugates
951297 France Detection Of Antigens Via Oligonucleotide Antibody Conjugates
951297 United Kingdom Detection Of Antigens Via Oligonucleotide Antibody Conjugates
3786970 Japan Detection Of Antigens Via Oligonucleotide Antibody Conjugates
2004239283 Australia Methods For Amplification Of Nucleic Acid Sequences Using Staggered Ligation
602004022282.8 Germany Methods For Amplification Of Nucleic Acid Sequences Using Staggered Ligation
1623044 European Patent Office Methods For Amplification Of Nucleic Acid Sequences Using Staggered Ligation
1623044 France Methods For Amplification Of Nucleic Acid Sequences Using Staggered Ligation
1623044 United Kingdom Methods For Amplification Of Nucleic Acid Sequences Using Staggered Ligation
171838 Israel Methods For Amplification Of Nucleic Acid Sequences Using Staggered Ligation
4599483 Japan Methods For Amplification Of Nucleic Acid Sequences Using Staggered Ligation
69834645.9 Germany Dendritic Nucleic Acids Exhibiting Maximal Self-Assembly
1005573 European Patent Office Dendritic Nucleic Acids Exhibiting Maximal Self-Assembly
1005573 France Dendritic Nucleic Acids Exhibiting Maximal Self-Assembly
1005573 United Kingdom Dendritic Nucleic Acids Exhibiting Maximal Self-Assembly
4221145 Japan Dendritic Nucleic Acids Exhibiting Maximal Self-Assembly
ZL200980113709.X China Methods, reagents and kits for detection of nucleic acid molecules
2320953 European Patent Office Long-Acting DNA Dendrimers and Methods Thereof